Mouse Semaphorin 4D (SEMA4D) Protein (Active)

Este producto es parte de SEMA4D - semaphorin 4D
Product Graph
1079€ (100 µg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Mouse Semaphorin 4D (SEMA4D) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx691990
tested applications
SDS-PAGE

Description

Mouse Semaphorin 4D Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the mouse SEMA4D (NP_038688.2) extracellular domain (Met 1-Arg 733) was expressed, with a C-terminal polyhistidine tag.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Semaphorin 4D
Host
HEK293 cells
Origin
Mouse
Observed MW
Molecular Weight: 80.2 kDa
Sequence Fragment: Met1-Arg733
Tag: C-terminal His tag
Validity: The validity for this protein is 12 months.
Expression
Recombinant
Purity
> 96% (SDS-PAGE)
Size 1
100 µg
Form
 
Tested Applications
SDS-PAGE
Buffer
Lyophilized from sterile PBS, pH 7.4.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
NCBI Accession
NP_038688.2
Alias
Semaphorin-4D,A8,GR3,BB18,CD100,COLL4,SEMAJ,coll-4,C9orf164,M-sema-G
Background
Protein SEMA4D
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

SEMA4D, also known as CD100, is a member of the semaphorin family, a group of proteins primarily involved in axonal guidance during neural development. SEMA4D was initially identified for its role in the nervous system, where it facilitates signaling for axonal growth and directionality. It is now known to have significant functions beyond neural tissue, impacting immune system responses, vascular biology, and cancer. By interacting with various receptor families, SEMA4D modulates cell-cell communication, cell migration, angiogenesis, and immune activation. In the immune system, SEMA4D is found on T cells, B cells, and dendritic cells, where it regulates immune responses by influencing cell adhesion, migration, and cytokine production. It has also become a molecule of interest in oncology, given its role in tumor progression, angiogenesis, and metastasis. SEMA4D is overexpressed in several cancer types, and its inhibition has shown promising results in reducing tumor growth and spread. Additionally, SEMA4D's involvement in blood vessel growth (angiogenesis) through its effects on endothelial cells and pericytes further highlights its importance in cancer biology and therapeutic potential.

Related Products

abx153052

Human Semaphorin 4D (SEMA4D) ELISA Kit

Human Semaphorin 4D (SEMA4D) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Semaphorin 4D (SEMA4D) concentrations in serum, plasma and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Semaphorin 4D (SEMA4D)

Ver Producto
abx492749

Human Semaphorin 4D (SEMA4D) CLIA Kit

Human Semaphorin 4D (SEMA4D) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Ver Producto
abx492750

Mouse Semaphorin 4D (SEMA4D) CLIA Kit

Mouse Semaphorin 4D (SEMA4D) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Serum, plasma, tissue homogenates and other biological fluids.

Ver Producto