Mouse S1PR1 (Sphingosine 1-phosphate receptor 1) ELISA Kit
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Mouse S1PR1 (Sphingosine 1-phosphate receptor 1) ELISA Kit
Category
ELISA Kits
Provider
FineTest
Reference
EM0608
Tested Applications
ELISA
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 0.156-10ng/ml |
| Sensitivity | 0.094ng/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | O08530 |
| Alias | S1PR1,CD363,CHEDG1,D1S3362,ECGF1,EDG-1,EDG1,S1P1,endothelial differentiation G protein-coupled receptor 1 |
| Background | Elisa kits for S1PR1 |
| Status | RUO |
Background
S1PR1 is a G protein-coupled receptor that binds sphingosine-1-phosphate (S1P), a bioactive lipid involved in immune regulation, vascular development, and cellular migration. S1PR1 is widely expressed in endothelial cells, lymphocytes, and smooth muscle cells, where it regulates vascular barrier integrity, immune cell trafficking, and angiogenesis. Activation of S1PR1 by S1P triggers signaling pathways involving Gi proteins, leading to activation of PI3K/Akt, MAPK, and Rac, which regulate cell survival, proliferation, and cytoskeletal dynamics. In the immune system, S1PR1 is critical for lymphocyte egress from lymphoid tissues into circulation, making it a key target for immunosuppressive therapies, such as fingolimod, used in treating multiple sclerosis. In the vasculature, S1PR1 maintains endothelial barrier function and regulates vascular permeability. Dysregulation of S1PR1 signaling is associated with inflammatory diseases, cardiovascular disorders, and cancer, where it promotes tumor angiogenesis and immune evasion. Therapeutically, S1PR1 modulators are being developed for autoimmune diseases, inflammatory conditions, and cancer, highlighting its critical role in immune and vascular homeostasis.
Productos relacionados
Sphingosine 1 Phosphate Receptor 1 (S1PR1) Antibody
Sphingosine-1-Phosphate Receptor 1 Antibody is a Rabbit Polyclonal antibody against Sphingosine-1-Phosphate Receptor 1.…
Ver producto
Human Sphingosine 1 Phosphate Receptor 1 (S1PR1) ELISA Kit
Human Sphingosine 1 Phosphate Receptor 1 (S1PR1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of …
Ver producto
Mouse Sphingosine 1 Phosphate Receptor 1 (S1PR1) ELISA Kit
Mouse Sphingosine 1 Phosphate Receptor 1 (S1PR1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of …
Ver producto