Mouse Proto-Oncogene Vav (VAV1) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein VAV1
proveedor
Abbexareference
abx168844Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Mouse VAV1 Protein is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Background
VAV1 is a guanine nucleotide exchange factor (GEF) that activates Rho family GTPases, such as Rac1 and Cdc42, by facilitating the exchange of GDP for GTP. It is primarily expressed in hematopoietic cells, where it plays a critical role in T-cell receptor (TCR) and B-cell receptor (BCR) signaling, cytoskeletal rearrangement, and immune cell activation. VAV1 acts as a signaling scaffold, linking tyrosine kinases to downstream effectors that regulate cell migration, adhesion, and polarization. It is essential for lymphocyte development, antigen receptor signaling, and immune responses. Dysregulation of VAV1 is associated with autoimmune diseases, impaired immune cell function, and certain cancers, including T-cell leukemia, where it promotes abnormal proliferation and survival. Knockout studies reveal defects in T-cell activation, impaired immune responses, and defective cytoskeletal organization, highlighting its critical role in immune signaling, cytoskeletal dynamics, and lymphocyte function.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
Proto-Oncogene Vav (VAV1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 30.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gly565-Ala795 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
VAV1
dry ice
No
availability
Shipped within 5-7 working days.
alias
VAV1, VAV,VAV1 protein,Proto-oncogene vav
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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