Mouse Protein Z (PROZ) Protein
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Description
Mouse Z Protein is a recombinant Mouse protein expressed in E. coli.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Protein Z (PROZ) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Ser23-Lys399 Tag: N-terminal His tag and GST tag |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 71.9 kDa Observed MW (SDS-PAGE): 72 kDa |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 100 mM NaHCO<sub>3</sub>, 500 mM NaCl, pH 8.3, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| Background | Protein PROZ |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in ddH2O to a concentration between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Descripción
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PROZ protein Z, vitamin K-dependent plasma glycoprotein.It is 62 kDa large and 396 amino acids long.It has four domains: a gla-rich region, two EGF-like domains and a trypsin-like domain.It lacks the serine residue that would make it catalytically active as a serine protease.It is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots.It is vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy.It is a glycoprotein.Although it is not enzymatically active, it is structurally related to several serine proteases of the coagulation cascade: factors VII, IX, X and protein C.The carboxyglutamate residues (which require vitamin K) bind protein Z to phospholipid surfaces.The main role of protein Z appears to be the degradation of factor Xa.This is done by protein Z-related protease inhibitor (ZPI), but the reaction is accelerated 1000-fold by the presence of protein Z.Oddly, ZPI also degrades factor XI, but this reaction does not require the presence of protein Z.In some studies, deficiency states have been associated with a propensity to thrombosis.Others, however, link it to bleeding tendency; there is no clear explanation for this, as it acts physiologically as an inhibitor, and deficiency would logically have led to a predisposition for thrombosis.
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