Mouse Protein Tyrosine Kinase 6 (PTK6) Protein (Active)
923€ (50 µg)
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935106861
info@markelab.com
name
Mouse Protein Tyrosine Kinase 6 (PTK6) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx693625
tested applications
SDS-PAGE
Description
Mouse PTK6 Protein is a recombinant protein from Mouse produced in Baculovirus-Insect Cells. A DNA sequence encoding the mouse PTK6 (Q64434) (Met1-Val451) was expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | PTK6 |
| Host | Insect |
| Origin | Mouse |
| Observed MW | Molecular Weight: 79.8 kDa Sequence Fragment: Met1-Val451 Tag: N-terminal His tag and GST tag Validity: The validity for this protein is 6 months. |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Supplied as sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% glycerol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q64434 |
| Alias | BRK,Breast tumor kinase, Tyrosine-protein kinase BRK |
| Background | Protein PTK6 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Protein Tyrosine Kinase 6 (PTK6), also known as BRK (Breast Tumor Kinase), is a non-receptor tyrosine kinase that is predominantly expressed in epithelial tissues and involved in regulating cell growth, differentiation, and stress responses. PTK6 is structurally similar to Src family kinases but functions independently of membrane localization. It contains an SH3 domain, SH2 domain, and a tyrosine kinase domain. PTK6 is localized in both the nucleus and cytoplasm, where it regulates distinct signaling pathways. In normal epithelial cells, PTK6 regulates differentiation and maintenance of tissue integrity. However, in cancers, particularly breast, colorectal, and prostate cancer, PTK6 is frequently upregulated and promotes cell proliferation, migration, and survival. PTK6 enhances signaling through pathways such as STAT3, AKT, and ERK1/2, contributing to tumor progression. Interestingly, PTK6 can also act as a tumor suppressor under certain conditions by promoting cell differentiation. Beyond cancer, PTK6 is involved in stress responses, including DNA damage repair and oxidative stress resistance. Its dual role in cell survival and differentiation makes PTK6 a potential therapeutic target in oncology.
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