Mouse Protein-tyrosine kinase 2-beta (PTK2B) ELISA Kit
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Mouse Protein-tyrosine kinase 2-beta (PTK2B) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse PTK2B concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Protein-tyrosine kinase 2-beta (PTK2B) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 78 pg/ml - 5000 pg/ml |
| Sensitivity | < 46.9 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9QVP9 |
| Gene ID | 19229 |
| Alias | PKB,PTK,CAKB,FAK2,PYK2,CADTK,FADK2,RAFTK,Proline-rich tyrosine kinase 2,Related adhesion focal tyrosine kinase,Calcium-regulated non-receptor proline-rich tyrosine kinase, Cell adhesion kinase beta,CAK-beta,Calcium-dependent tyrosine kinase |
| Background | Elisa kits for PTK2B |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Protein Tyrosine Kinase 2 Beta (PTK2B), also known as Pyk2, is a cytoplasmic tyrosine kinase related to PTK2 but has distinct roles in calcium signaling, immune responses, and neuronal function. PTK2B is activated by increased intracellular calcium levels, G-protein-coupled receptors (GPCRs), and environmental stress. Structurally, PTK2B shares a similar architecture with PTK2, including an FERM domain, kinase domain, and focal adhesion targeting region, but has a unique sensitivity to calcium signaling. PTK2B regulates cytoskeletal dynamics, cell adhesion, and migration, particularly in immune cells and neurons. PTK2B is highly expressed in the nervous system and plays a pivotal role in synaptic plasticity, neuronal migration, and memory formation. Its overactivation has been linked to neurodegenerative diseases such as Alzheimer’s disease by modulating tau phosphorylation and beta-amyloid signaling. In the immune system, PTK2B influences macrophage activation, B-cell responses, and inflammatory signaling pathways. Dysregulation of PTK2B is also associated with certain cancers, where it promotes cell survival, invasion, and tumor progression. Targeting PTK2B is being explored for potential therapeutic interventions in cancer and neuroinflammation.
Related Products
PTK2B (pY402) Antibody
PTK2B (pY402) Antibody is a Rabbit Polyclonal antibody against PTK2B (pY402). This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
Ver Producto
Protein-Tyrosine Kinase 2-Beta Phospho-Tyr402 (PTK2B pY402) Antibody
Rabbit polyclonal antibody against PYK2 protein. Immunogen region is Internal. Specificity is as follows for the reactive species: H:Y402, M:Y402, R:Y402.
Ver Producto
Protein-Tyrosine Kinase 2-Beta Phospho-Tyr579 (PTK2B pY579) Antibody
Rabbit polyclonal antibody against PYK2 protein. Immunogen region is Internal. Specificity is as follows for the reactive species: H:Y579, M:Y579, R:Y579.
Ver Producto