Mouse Protein Argonaute 2 (AGO2) Protein
819€ (20 µg)
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935106861
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name
Mouse Protein Argonaute 2 (AGO2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx693433
tested applications
SDS-PAGE
Description
Mouse AGO2 Protein is a recombinant protein from Mouse produced in Baculovirus-Insect Cells. A DNA sequence encoding the mouse AGO2 (Q8CJG0) (Met 1-Ala 860) was fused with a polyhistidine tag at the N-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | AGO2 |
| Host | Insect |
| Origin | Mouse |
| Observed MW | Molecular Weight: 99 kDa Sequence Fragment: Met1-Ala860 Tag: N-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 88% (SDS-PAGE) |
| Size 1 | 20 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8CJG0 |
| Alias | CASC7,EIF2C2,LESKRES,LINC00980,PPD,Q10 |
| Background | Protein AGO2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
AGO2 is the most well-characterized and catalytically active member of the Argonaute family, playing a central role in the RISC complex. AGO2 binds miRNAs and small interfering RNAs (siRNAs) to mediate both translational repression and endonucleolytic cleavage (slicing) of target mRNAs. Its conserved PIWI domain is responsible for its slicer activity, enabling AGO2 to degrade complementary mRNA targets directly. AGO2 is highly expressed in many tissues and is involved in crucial cellular processes, including gene silencing, developmental regulation, and the cellular response to viral infections. Dysregulation of AGO2 contributes to various pathological conditions, including cancers, neurodegenerative diseases, and immune disorders, due to its impact on gene expression and miRNA/siRNA pathways. AGO2 is also being explored as a potential therapeutic target in RNA-based therapies.
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