Mouse Protein Argonaute-2 (AGO2) Protein
780€ (20 µg)
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935106861
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name
Mouse Protein Argonaute-2 (AGO2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx693433
tested applications
SDS-PAGE
Description
Protein Argonaute-2 (AGO2) protein is a recombinant Mouse protein expressed in Insect.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Protein Argonaute-2 (AGO2) |
| Host | Insect |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Ala860 Tag: N-terminal His tag |
| Origin | Mouse |
| Observed MW | 99 kDa |
| Expression | Recombinant |
| Purity | > 88% (SDS-PAGE) |
| Size 1 | 20 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: Sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10% glycerol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | Q8CJG0 |
| Alias | CASC7,EIF2C2,LESKRES,LINC00980,PPD,Q10 |
| Background | Protein AGO2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Descripción
AGO2 is the most well-characterized and catalytically active member of the Argonaute family, playing a central role in the RISC complex. AGO2 binds miRNAs and small interfering RNAs (siRNAs) to mediate both translational repression and endonucleolytic cleavage (slicing) of target mRNAs. Its conserved PIWI domain is responsible for its slicer activity, enabling AGO2 to degrade complementary mRNA targets directly. AGO2 is highly expressed in many tissues and is involved in crucial cellular processes, including gene silencing, developmental regulation, and the cellular response to viral infections. Dysregulation of AGO2 contributes to various pathological conditions, including cancers, neurodegenerative diseases, and immune disorders, due to its impact on gene expression and miRNA/siRNA pathways. AGO2 is also being explored as a potential therapeutic target in RNA-based therapies.
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