Mouse Pregnancy Associated Plasma Protein A (PAPPA) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
525€ (96 tests)
Elisa Kits PAPPA
proveedor
Abbexareference
abx254812Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Pregnancy Associated Plasma Protein A (PAPPA) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Pregnancy Associated Plasma Protein A concentrations in serum, plasma and other biological fluids.
Background
PAPPA, also known as pregnancy-associated plasma protein-A, is a zinc-binding metalloproteinase that regulates the activity of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins (IGFBPs), specifically IGFBP-4 and IGFBP-5. This proteolytic activity increases the bioavailability of IGFs, which are crucial for cell growth, proliferation, and tissue repair. PAPPA is highly expressed during pregnancy, where it contributes to placental development and fetal growth, making it a key biomarker in prenatal screening for conditions like preeclampsia and Down syndrome. Outside of pregnancy, PAPPA is involved in regulating processes such as bone remodeling, wound healing, and inflammation. Elevated PAPPA expression has been observed in cardiovascular diseases and certain cancers, where it promotes IGF-mediated cell proliferation and tumor progression. Its role in modulating IGF signaling highlights its importance in both physiological and pathological conditions.
Características del producto
category
ELISA Kits
immunogen target
Pregnancy Associated Plasma Protein A (PAPPA)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
sensitivity
0.1 ng/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Serum,Plasma,Other biological fluids
size 1
96 tests
alias
PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
PAPPA
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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