Mouse Poliovirus Receptor (PVR) Protein
585€ (50 µg)
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935106861
info@markelab.com
name
Mouse Poliovirus Receptor (PVR) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx692734
tested applications
SDS-PAGE
Description
Mouse CD155 Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the mouse CD155 (NP_081790.1) precursor (Met 1-Arg 345) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | CD155 |
| Host | HEK293 cells |
| Origin | Mouse |
| Observed MW | Molecular Weight: 63 kDa Sequence Fragment: Met1-Arg345 Tag: C-terminal His tag and Fc tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_081790.1 |
| Alias | Poliovirus receptor,PVS,HVED,CD155,NECL5,TAGE4,Necl-5,Nectin-like protein 5 |
| Background | Protein PVR |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
PVR, also known as CD155, is a cell adhesion molecule primarily involved in cell signaling, immune modulation, and viral entry. The gene encoding this protein is found on chromosome 19q13.31, and the protein was initially identified as the receptor for poliovirus, facilitating viral entry into cells. However, PVR is not limited to viral entry functions; it plays a significant role in immune cell interactions, migration, and tissue development. Structurally part of the immunoglobulin superfamily, PVR is widely expressed in various tissues, including epithelial cells, endothelial cells, and immune cells, and is upregulated in certain cancers, suggesting an adaptive role in tumor immune escape mechanisms. This protein is a primary ligand for several immune checkpoints such as DNAM-1 (CD226), TIGIT, and CD96, highlighting its importance in immune system modulation.
