Mouse Platelet Derived Growth Factor Receptor Beta (PDGFRB) Protein
234€ (10 µg)
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Name
Mouse Platelet Derived Growth Factor Receptor Beta (PDGFRB) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx068588
Tested Applications
WB, SDS-PAGE
Description
Mouse Platelet Derived Growth Factor Receptor Beta (PDGFRb) is a recombinant Mouse protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Platelet Derived Growth Factor Receptor Beta (PDGFRB) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Val337-Pro583 Tag: N-terminal His tag |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 32.0 kDa Observed MW (SDS-PAGE): 38 kDa |
| Expression | Recombinant |
| Purity | > 97% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | P05622 |
| Alias | IMF1,KOGS,IBGC4,JTK12,PDGFR,PENTT,CD140B,PDGFR1,PDGFR-1,CD140 antigen-like family member B,Platelet-derived growth factor receptor 1,Beta-type platelet-derived growth factor receptor,PDGF-R-beta,PDGFR-beta |
| Background | Protein PDGFRB |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
Platelet derived growth factor receptor beta (PDGFRB) similarly functions as a receptor for PDGFs and is crucial for vascular development and the regulation of blood vessel maturation and stability PDGFRB is expressed in pericytes and vascular smooth muscle cells, where it modulates cell migration, proliferation, and differentiation its activation is pivotal in angiogenesis and vascular remodeling through downstream signaling pathways including STAT3 and Ras-MAPK aberrations in PDGFRB signaling are implicated in pathologies such as proliferative retinopathies, atherosclerosis, and certain myeloproliferative disorders including chronic eosinophilic leukemia targeted inhibitors have been developed to counteract PDGFRB-driven malignancies while new studies focus on its contribution to immune modulation and tissue regeneration.
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