Mouse Plasminogen Activator Inhibitor 2 (SERPINB2) ELISA Kit
proveedor
Abbexareference
abx154501Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Plasminogen Activator Inhibitor 2 (SERPINB2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Plasminogen Activator Inhibitor 2 (SERPINB2) concentrations in plasma. This assay has high sensitivity and excellent specificity for detection of PAI2 (PAI2)No significant cross-reactivity or interference between PAI2 (PAI2) and analogues was observed.
Background
Inhibitory serpins have been shown to function in processes as diverse as DNA binding, chromatin condensation, immunoregulation ,apoptosis and haemostasis. Serpins are a broadly distributed protease inhibitors that use the conformational change as a mechanism of action. They are central in controlling many important proteolytic cascades. Phylogenetically Serpins superfamily organized in "Clades", named by letters. The following numbers shows the position in the glade. Serpin named as a SERPINXy, (where X is the clade and y is the number within that clade) many serpins also have alternative names from before this classification was proposed. Structuraly Serpinsare three β-sheets (A, B and C), 8-9 α-helices (termed hA-hI) and the reactive center known as reactive center loop (RCL). PAI-2 or Plasminogen activator inhibitor-2 (placental PAI, SerpinB2), is a serine protease inhibitor of the serpin superfamily. It is a coagulation factor that inactivates tissue plasminogen activator and urokinase. It is present in most cells, especially monocytes/macrophages
Background
Se ha demostrado que las serpinas inhibidoras funcionan en procesos tan diversos como la unión al ADN, la condensación de cromatina, la inmunorregulación, la apoptosis y la hemostasia. Las serpinas son inhibidores de proteasas ampliamente distribuidos que utilizan el cambio conformacional como mecanismo de acción. Son fundamentales para controlar muchas cascadas proteolíticas importantes. Filogenéticamente superfamilia de Serpinas organizada en "Clados", nombradas por letras. Los siguientes números muestran la posición en el claro. Serpin nombrada como SERPINXy (donde X es el clado e y es el número dentro de ese clado). Muchas serpinas también tienen nombres alternativos antes de que se propusiera esta clasificación. Estructuralmente, las Serpins son tres láminas β (A, B y C), 8-9 hélices α (denominadas hA-hI) y el centro reactivo conocido como bucle del centro reactivo (RCL). PAI-2 o inhibidor del activador del plasminógeno-2 (PAI placentario, SerpinB2), es un inhibidor de la serina proteasa de la superfamilia de las serpinas. Es un factor de coagulación que inactiva el activador del plasminógeno tisular y la uroquinasa. Está presente en la mayoría de las células, especialmente monocitos/macrófagos.
Características del producto
category
ELISA Kits
immunogen target
Plasminogen Activator Inhibitor 2 (SERPINB2)
reactivity
Mouse
test range
7.8 pg/ml - 500 pg/ml
sensitivity
< 3.3 pg/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Plasma
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
PAI,PAI2,PAI-2,PLANH2,HsT1201,Plasminogen activator inhibitor 2,Monocyte Arg-serpin,Placental plasminogen activator inhibitor,Serpin B2
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
SERPINB2
dry ice
No
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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