Mouse Phosphoglycerate Kinase 1 (PGK1) Protein (Active)
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Description
Mouse PGK1 Protein is a recombinant protein from Mouse produced in Baculovirus-Insect Cells. A DNA sequence encoding the mouse PGK1 (P09411) (Met 1-Val 417) was expressed, with a C-terminal polyhistidine tag.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | PGK1 |
| Host | Insect |
| Origin | Mouse |
| Observed MW | Molecular Weight: 46 kDa Sequence Fragment: Met1-Val417 Tag: C-terminal His tag Validity: The validity for this protein is 6 months. |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 50 µg |
| Tested Applications | SDS-PAGE |
| Buffer | Supplied as sterile 20mM Tris, 500mM NaCl, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P09411 |
| Background | Protein PGK1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
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The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1, 3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome.
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