Mouse Peroxisome Proliferator Activated Receptor Gamma (PPARg) Protein

Este producto es parte de PPAR - peroxisome proliferator activated receptor
Mouse Peroxisome Proliferator Activated Receptor Gamma (PPARg) Protein
247€ (10 µg)

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Name
Mouse Peroxisome Proliferator Activated Receptor Gamma (PPARg) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx652141
Tested Applications
WB, SDS-PAGE

Description

Mouse Peroxisome Proliferator Activated Receptor Gamma (PPARg) Protein is a recombinant protein from Mouse.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
Peroxisome Proliferator Activated Receptor Gamma (PPARg)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Lys347-Glu488
Tag: N-terminal His tag
Origin
Mouse
Conjugation
Unconjugated
Observed MW
Calculated MW: 17.5 kDa  Observed MW (SDS-PAGE): 18 kDa
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
UniProt ID
P37238
Alias
GLM1,CIMT1,NR1C3,PPARG1,PPARG2,PPARG5,PPARgamma,Nuclear receptor subfamily 1 group C member 3
Background
Protein PPARG
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

Peroxisome proliferator activated receptor gamma (PPARG) is a nuclear receptor that plays a central role in the regulation of glucose and lipid metabolism, adipogenesis, and inflammation PPARG is highly expressed in adipose tissue, where it regulates the differentiation of preadipocytes into mature adipocytes and controls the storage of fatty acids PPARG also modulates the expression of genes involved in insulin sensitivity, glucose homeostasis, and lipid storage, and it is a critical factor in maintaining metabolic balance Dysregulation of PPARG has been associated with a variety of metabolic disorders, including type 2 diabetes, obesity, and cardiovascular disease PPARG is a major target for drugs like thiazolidinediones (TZDs), which are used to improve insulin sensitivity in type 2 diabetes However, PPARG activation also influences immune responses and inflammation, and its role in chronic inflammation has linked it to diseases such as atherosclerosis and cancer Modulating PPARG activity offers therapeutic potential for addressing metabolic diseases, inflammatory conditions, and cancer, making it an important target for drug development in multiple areas of medicine

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