Mouse Peroxisome Proliferator Activated Receptor Alpha (PPARa) Protein
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Description
Mouse PPARA Protein is a recombinant Mouse protein expressed in E. coli.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Peroxisome Proliferator Activated Receptor Alpha (PPARa) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 46.9 kDa Observed MW (SDS-PAGE): 47 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ser280-Leu433 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P23204 |
| Alias | PPAR,NR1C1,Hppar,PPARalpha,PPAR-alpha,Nuclear receptor subfamily 1 group C member 1 |
| Background | Protein PPARA |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Peroxisome proliferator activated receptor alpha (PPARA) is a nuclear hormone receptor that plays a critical role in the regulation of lipid metabolism, inflammation, and energy homeostasis PPARA is primarily expressed in tissues involved in fatty acid metabolism, such as the liver, heart, and skeletal muscle, where it regulates the transcription of genes involved in the breakdown of fatty acids and lipids The receptor functions by binding to specific ligands, such as fatty acids and fibrates, which activate PPARA and induce the expression of genes involved in lipid catabolism, mitochondrial biogenesis, and oxidative stress response PPARA is also involved in regulating glucose metabolism and insulin sensitivity, making it a key player in metabolic diseases like diabetes and obesity Dysregulation of PPARA has been linked to various disorders, including cardiovascular diseases, metabolic syndrome, and fatty liver disease PPARA's role in regulating inflammation further highlights its therapeutic potential in conditions characterized by chronic inflammation, including atherosclerosis and neurodegenerative diseases
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