Mouse NLRP1 (NLR Family, Pyrin Domain Containing 1) QuickTest ELISA Kit
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Product specifications
| Category | ELISA Kits |
| Reactivity | Mouse |
| Assay Data | 120 minutes |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 7.813-500pg/ml |
| Sensitivity | 4.688pg/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma, cell culture supernatant, cell lysate or tissue lysate, other biological fluid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | Q2LKU9 |
| Alias | NACHT, LRR and PYD domains-containing protein 1a, Caspase recruitment domain-containing protein 7, Death effector filament-forming ced-4-like apoptosis protein, Nucleotide-binding domain and caspase recruitment domain, Nlrp1a, Card7, Nalp1, Nalp1a, Nlrp1 |
| Background | Elisa kits for NLRP1 |
| Status | RUO |
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Mouse NLRP1 (NLR Family, Pyrin Domain Containing 1) ELISA Kit
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NLRP1 antibody
As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP1, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death(PubMed:22665479, PubMed:17418785). May be activated by muramyl dipeptide(MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner(PubMed:18511561). Contrary to its mouse ortholog, not activated by Bacillus anthracis lethal toxin(PubMed:19651869). It is unclear whether isoform 2 is involved in inflammasome formation. It is not cleaved within the FIIND domain, does not assemble into specks, nor promote IL1B release(PubMed:22665479). However, in an vitro cell-free system, it has been shown to be activated by MDP(PubMed:17349957). Binds ATP(PubMed:11113115, PubMed:15212762).
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