Mouse Neurogenic Locus Notch Homolog Protein 1 (NOTCH1) Protein (Active)
702€ (50 µg)
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Name
Mouse Neurogenic Locus Notch Homolog Protein 1 (NOTCH1) Protein (Active)
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx691901
Tested Applications
SDS-PAGE
Description
Neurogenic Locus Notch Homolog Protein 1 (NOTCH1) protein is a recombinant Mouse protein expressed in Insect.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Neurogenic Locus Notch Homolog Protein 1 (NOTCH1) |
| Host | Insect |
| Assay Type | Activity: Active Sequence Fragment: Met1-Gln526 Tag: C-terminal His tag |
| Origin | Mouse |
| Observed MW | 55 kDa |
| Expression | Recombinant |
| Purity | > 82% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: Sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10% glycerol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | Q01705 |
| NCBI Accession | NP_032740.3 |
| Alias | AOS5,AOVD1,TAN1,Hn1,Translocation-associated notch protein TAN-1,notch receptor 1 |
| Background | Protein NOTCH1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Background
NOTCH1 is a transmembrane receptor of the Notch signaling pathway, which regulates critical processes such as cell fate determination, proliferation, differentiation, and apoptosis during development and tissue homeostasis. Upon ligand binding (e.g., Jagged or Delta-like ligands), the NOTCH1 receptor undergoes proteolytic cleavage, releasing its intracellular domain (NICD). NICD translocates to the nucleus, activating transcription of target genes, including HES and HEY family members, to modulate cell behavior. Dysregulation of NOTCH1 contributes to various diseases, including cancers such as T-cell acute lymphoblastic leukemia (T-ALL), where activating mutations drive aberrant proliferation. In addition, NOTCH1 plays a role in cardiovascular development, neural differentiation, and immune system regulation. Knockout studies reveal embryonic lethality due to disrupted vascular development and neurogenesis, demonstrating its essential role in embryonic and adult tissue homeostasis, cellular differentiation, and oncogenesis.
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