Mouse N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (GCNT2) ELISA Kit
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Description
Mouse N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (GCNT2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (GCNT2) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P97402 |
| Gene ID | 14538 |
| Alias | N-acetylglucosaminyltransferase,I-branching enzyme,CCAT,CTRCT13,GCNT2C,GCNT5,IGNT,NACGT1,NAGCT1,ULG3,bA360O19.2,bA421M1.1 |
| Background | Elisa kits for GCNT2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Glucosaminyl (N-acetyl) transferase 2 (GCNT2), also known as the I-branching enzyme, catalyzes the addition of N-acetylglucosamine to linear oligosaccharides, forming the branched I antigen structure that characterizes the I blood group system GCNT2 is predominantly expressed in erythroid cells, epithelial tissues, and during embryonic development, where it is critical for glycan diversity and proper glycoprotein function Mutations in GCNT2 lead to the adult i phenotype, a rare blood group disorder characterized by persistent fetal-type linear glycans, hemolytic anemia, and immune vulnerabilities GCNT2’s activity also influences ocular health, with mutations linked to congenital cataracts and other lens abnormalities Emerging research highlights its role in embryogenesis and cell surface glycosylation, critical for cell signaling, adhesion, and differentiation Dysregulation of GCNT2 expression has further been associated with immune dysfunction and specific cancer pathways, emphasizing its role in glycoprotein branching and cellular homeostasis
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This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1, 6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described.
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