Mouse Muscarinic Acetylcholine Receptor M4 (CHRM4) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Mouse Muscarinic Acetylcholine Receptor M4 (CHRM4) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx500783
tested applications
ELISA
Description
Mouse Muscarinic acetylcholine receptor M4 (CHRM4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Muscarinic acetylcholine receptor M4 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Muscarinic Acetylcholine Receptor M4 (CHRM4) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.07 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P32211 |
| Gene ID | 12672 |
| Alias | CHRM4,Chrm-4,cholinergic receptor, muscarinic 4,cholinergic receptor,M4 receptor,HM4, M4R |
| Background | Elisa kits for CHRM4 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
CHRM4 encodes the muscarinic acetylcholine receptor M4, a member of the G protein-coupled receptor (GPCR) family that predominantly couples with Gi/o proteins. When activated by acetylcholine, CHRM4 inhibits adenylate cyclase, leading to a decrease in intracellular cyclic AMP (cAMP) levels and subsequent regulation of cellular excitability. CHRM4 is widely expressed in the central nervous system (CNS), particularly in regions like the striatum, basal ganglia, and hippocampus, where it plays a pivotal role in dopaminergic signaling and motor control. CHRM4 is a crucial modulator of dopamine release and has gained interest as a therapeutic target for disorders such as Parkinson's disease, schizophrenia, and addiction. In preclinical models, CHRM4 activation has been shown to suppress dopamine overactivity, which is associated with psychotic symptoms in schizophrenia. CHRM4 also plays roles in mood regulation, cognition, and neuromodulation by influencing cholinergic-dopaminergic interactions. Genetic variations in CHRM4 may affect susceptibility to neuropsychiatric diseases. Pharmacologically, CHRM4-selective agonists are under exploration for their ability to normalize dopamine levels, while antagonists have been evaluated for their effects on smooth muscle tone in peripheral tissues.
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