Mouse Muscarinic acetylcholine receptor M3 (CHRM3) CLIA Kit
845€ (96 tests)
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935106861
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name
Mouse Muscarinic acetylcholine receptor M3 (CHRM3) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx493147
tested applications
CLIA
Description
Mouse Muscarinic acetylcholine receptor M3 (CHRM3) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Muscarinic acetylcholine receptor M3 (CHRM3) |
| Reactivity | Mouse |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.113 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | CHRM3,Chrm-3,M3R,cholinergic receptor, muscarinic 3,cholinergic receptor,cholinergic receptor, muscarinic 3, cardiac,M3 receptor,HM3, PBS, EGBRS, m3AChR |
| Background | CLIA Kits CHRM3 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
CHRM3 encodes the cholinergic receptor muscarinic 3, another receptor in the muscarinic acetylcholine receptor family that primarily couples to Gq/11 proteins. Upon activation by acetylcholine, CHRM3 stimulates phospholipase C (PLC), leading to increased production of inositol triphosphate (IP3) and diacylglycerol (DAG), which together elevate intracellular calcium ion concentrations and activate downstream signaling pathways. CHRM3 is abundantly expressed in smooth muscle tissues of the gastrointestinal tract, bladder, and lungs, where it plays a key role in mediating smooth muscle contraction. It is critical for processes such as gastrointestinal motility, bronchoconstriction, and urinary bladder contraction. In the CNS, CHRM3 contributes to cognitive function and neuronal signaling. Dysregulation of CHRM3 has been implicated in disorders like overactive bladder syndrome, asthma, and certain types of cancer. Pharmacologically, CHRM3 antagonists, such as antimuscarinics, are used to treat conditions like overactive bladder, while agonists could be explored for potential use in cognitive enhancement. CHRM3 remains a critical target for both autonomic regulation and emerging therapies in neurological disorders and cancer research.
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