Mouse Mineralocorticoid Receptor (NR3C2) ELISA Kit

Product specifications

ELISA Kits

Mineralocorticoid Receptor (NR3C2)

Mouse

Colorimetric

Quantitative

Sandwich

0.156 ng/ml - 10 ng/ml

< 0.09 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-12 working days. The validity for this kit is 6 months.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

Q8VII8

MR,MCR,MLR,NR3C2VIT,Mineralocorticoid receptor

Elisa kits for NR3C2

RUO

Validity: The validity for this kit is 6 months.

This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

Nuclear receptor subfamily 3 group C member 2 (NR3C2), also known as the mineralocorticoid receptor (MR), is a nuclear receptor that mediates the effects of mineralocorticoids, particularly aldosterone, which regulates salt and water balance, blood pressure, and electrolyte homeostasis NR3C2 is primarily expressed in the kidneys, heart, and brain, where it controls the reabsorption of sodium and water, influencing blood volume and pressure It functions by binding to aldosterone and translocating to the nucleus, where it regulates the expression of genes involved in electrolyte balance and fluid retention NR3C2 is essential for maintaining blood pressure and regulating the body's response to dehydration and salt imbalances Dysregulation of NR3C2 has been linked to various cardiovascular and renal disorders, including hypertension, heart failure, and kidney disease Overactivation of MR signaling can lead to fluid retention and hypertension, while decreased activity can result in conditions like hypoaldosteronism In addition, MR is a target for drugs such as mineralocorticoid antagonists, which are used to treat conditions like heart failure and hypertension

Related Products

NR3C2 antibody

Receptor for both mineralocorticoids(MC) such as aldosterone and glucocorticoids(GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements(MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.

Ver Producto

Mineralocorticoid Receptor (NR3C2) Antibody

NR3C2 Antibody is a Rabbit Polyclonal antibody against NR3C2. This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.

Ver Producto

Mineralocorticoid Receptor (NR3C2) Antibody

Mineralocorticoid Receptor Antibody is a Rabbit Polyclonal against Mineralocorticoid Receptor.

Ver Producto