Mouse Tissue Inhibitor of MetalloProtein is a recombinant protein from Mouse produced in Human Cells. Recombinant Mouse Tissue Inhibitor of Metalloproteinases 2 is produced by our Mammalian expression system and the target gene encoding Cys27-Pro220 is expressed with a 6His tag at the C-terminus.
MMPs are secreted by diverse connective tissue and pro-inflammatory cells. Typically, these enzymes exhibit minimal expression under normal physiological circumstances. MMPs assume a pivotal role in various cellular processes, including cell proliferation, migration, differentiation, angiogenesis, apoptosis, and immunity. They share a common domain structure, consisting of three key components. First is the pro-peptide, which requires removal to activate the enzyme. Next, there is the catalytic domain, featuring a cysteine switch, where a cysteine residue interacts with zinc, and the haemopexin-like C-terminal domain is linked to the catalytic domain via a flexible hinge region. TIMP-2 (Tissue Inhibitor of Metalloproteinases 2) is indeed a natural inhibitor of the matrix metalloproteinases (MMPs). It forms complexes with certain enzymes within the metalloproteinase family, leading to their irreversible inactivation. TIMP-2 is known to act on a wide range of MMPs, including MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16, and MMP-19. Interestingly, TIMP-2 shares a significant degree of amino acid sequence homology, about 40%, with TIMP-1, especially in their N-terminal domains. This structural similarity underscores their related functions as inhibitors of metalloproteinases, despite some differences in their specific roles and affinities for certain MMPs.
Proteins and Peptides
Mouse
Human
Metalloproteinase Inhibitor 2 (TIMP2)
Human
SDS-PAGE
10 µg
50 µg
Recombinant
> 95% (SDS-PAGE)
20mM TrisHCl, 150mM NaCl, pH7.5.
Aliquot and store at < -20 °C. Avoid repeated freeze/thaw cycles.
TIMP2
No
Shipped within 5-15 working days.
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
Pig Metalloproteinase Inhibitor 2 (TIMP2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Pig Met...
712.5€ (96 tests)
Ver másGuinea pig Metalloproteinase Inhibitor 2 (TIMP2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of ...
537.5€ (96 tests)
Ver másTissue Inhibitors of Metalloproteinase 2 (TIMP-2) Antibody is a Sheep Polyclonal antibody against Tissue Inhibitors of M...
350€ (1 ml)
Ver más