Mouse Metalloproteinase Inhibitor 1 (TIMP1) Protein
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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein TIMP1
proveedor
Abbexareference
abx069330Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Background
TIMP1 is a member of the TIMP family and acts as a natural inhibitor of matrix metalloproteinases (MMPs), which are enzymes that degrade components of the extracellular matrix TIMP1 regulates tissue remodeling, inflammation, and wound healing by inhibiting MMP activity and preventing excessive matrix breakdown It also exhibits anti-apoptotic properties by binding to cell surface receptors and activating survival pathways TIMP1 plays a role in cancer progression where its overexpression can inhibit tumor invasion and metastasis by limiting MMP activity, while paradoxically, it can also promote tumor growth by stimulating cell proliferation and angiogenesis Dysregulation of TIMP1 is observed in diseases such as fibrosis, cardiovascular disease, and chronic inflammatory conditions, where altered MMP activity contributes to tissue damage and remodeling TIMP1’s dual role as a regulator of extracellular matrix turnover and cell signaling makes it a key player in both normal physiological processes and pathological conditions
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
Metalloproteinase Inhibitor 1 (TIMP1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 15.3 kDa Observed MW (SDS-PAGE): 15 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala35-Pro160 Tag: N-terminal His tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
TIMP1
dry ice
No
availability
Shipped within 5-7 working days.
alias
Tissue inhibitor of metalloproteinases 1,EPA,EPO,HCI,CLGI,TIMP,TIMP-1
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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