Mouse Matrix Metalloproteinase 17 (MMP17) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse MMP17 concentrations in serum, plasma, tissue homogenates, cell lysates and other biological fluids.
MMPs are secreted by diverse connective tissue and pro-inflammatory cells. Typically, these enzymes exhibit minimal expression under normal physiological circumstances. MMPs assume a pivotal role in various cellular processes, including cell proliferation, migration, differentiation, angiogenesis, apoptosis, and immunity. They share a common domain structure, consisting of three key components. First is the pro-peptide, which requires removal to activate the enzyme. Next, there is the catalytic domain, featuring a cysteine switch, where a cysteine residue interacts with zinc, and the haemopexin-like C-terminal domain is linked to the catalytic domain via a flexible hinge region. MMP-17, also recognized as membrane-type matrix metalloproteinase 4 (MT-MMP 4), is an enzyme encoded by the MMP17 gene in humans. It is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) . High expression of this protein has been observed in conditions such as osteoarthritis and multiple human cancers. It also goes by aliases including MT4-MMP, MMP-17, MT4MMP, and MTMMP4.
MMPs son secretadas por diversos tejidos conectivos y células proinflamatorias. Normalmente, estas enzimas exhiben una expresión mínima en circunstancias fisiológicas normales. Las MMP asumen un papel fundamental en diversos procesos celulares, incluida la proliferación, migración, diferenciación, angiogénesis, apoptosis e inmunidad celular. Comparten una estructura de dominio común, que consta de tres componentes clave. El primero es el propéptido, que requiere eliminación para activar la enzima. A continuación, está el dominio catalítico, que presenta un interruptor de cisteína, donde un residuo de cisteína interactúa con el zinc, y el dominio C-terminal similar a hemopexina está unido al dominio catalítico a través de una región bisagra flexible. MMP-17, también reconocida como metaloproteinasa 4 de matriz de tipo membrana (MT-MMP 4), es una enzima codificada por el gen MMP17 en humanos. Está anclado a la membrana celular mediante un anclaje de glicosilfosfatidilinositol (GPI). Se ha observado una expresión elevada de esta proteína en afecciones como la osteoartritis y múltiples cánceres humanos. También tiene alias que incluyen MT4-MMP, MMP-17, MT4MMP y MTMMP4.
ELISA Kits
Matrix Metalloproteinase 17 (MMP17)
Mouse
0.156 ng/ml - 10 ng/ml
0.1 ng/ml
Sandwich
Quantitative
Colorimetric
Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids
96 tests
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
MMP17
No
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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