Mouse Lysosomal Associated Membrane Protein 2 (LAMP2) Protein

Este producto es parte de LAMP- Lysosomal Associated Membrane Protein
Mouse Lysosomal Associated Membrane Protein 2 (LAMP2) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein LAMP2

proveedor

Abbexa

reference

abx067863

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Lysosomal Associated Membrane Protein 2 (LAMP2) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

Lysosome-associated membrane glycoprotein 2 (LAMP2) is a critical lysosomal membrane protein involved in autophagy, lysosomal biogenesis, and cellular homeostasis LAMP2 facilitates the fusion of autophagosomes with lysosomes, enabling the degradation of cellular components during autophagy LAMP2 exists in three isoforms (LAMP2A, LAMP2B, and LAMP2C), each with distinct roles in lysosome function LAMP2A is essential for chaperone-mediated autophagy (CMA), where it mediates the selective degradation of cytosolic proteins LAMP2B is primarily involved in macroautophagy, particularly in muscle and neuronal tissues Mutations in LAMP2 cause Danon disease, a rare lysosomal storage disorder characterized by cardiomyopathy, myopathy, and intellectual disability LAMP2 dysregulation has been linked to neurodegenerative diseases and cancers, where impaired autophagy disrupts cellular homeostasis and promotes disease progression LAMP2 also plays a role in immune responses, contributing to antigen processing and lysosomal exocytosis Its importance in autophagy, cellular stress responses, and disease underscores its critical role in maintaining cellular integrity

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

Lysosomal Associated Membrane Protein 2 (LAMP2)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 45.4 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asn295-Thr410 Tag: N-terminal His tag and GST tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

LAMP2


dry ice

No


availability

Shipped within 5-7 working days.


alias

CD107b,DND,LAMP-2,LAMPB,LGP-96,LGP110


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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