Mouse Lymphokine-Activated Killer T-Cell-Originated Protein Kinase (PBK) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Mouse Lymphokine-Activated Killer T-Cell-Originated Protein Kinase (PBK) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx390175
tested applications
ELISA
Description
Mouse Lymphokine-activated killer T-cell-originated protein kinase (PBK) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse PBK concentrations in serum, plasma and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Lymphokine-Activated Killer T-Cell-Originated Protein Kinase (PBK) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 78 pg/ml - 5000 pg/ml |
| Sensitivity | < 24.0 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9JJ78 |
| Gene ID | 52033 |
| Alias | CT84,HEL164,Nori-3,SPK,TOPK,Cancer/testis antigen 84,Spermatogenesis-related protein kinase |
| Background | Elisa kits for PBK |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
PDZ Binding Kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase that is predominantly expressed in proliferating cells and is associated with cell cycle regulation, particularly during the G2/M transition. It is highly active in mitosis, phosphorylating substrates such as histone H3 to regulate chromatin condensation and cell division. PBK is implicated in signaling pathways involving MAPKs and Akt, contributing to cell survival, proliferation, and response to stress stimuli. Overexpression of PBK has been observed in various cancers, including lung, breast, and colorectal cancers, where it promotes oncogenic traits like enhanced proliferation, invasion, and resistance to apoptosis. It has also been linked to the regulation of immune responses, influencing T-cell activation and cytokine production. PBK is tightly regulated through phosphorylation by upstream kinases, such as Cyclin-dependent kinases, and dephosphorylation by phosphatases like PP2A, which ensures its activity is restricted to specific phases of the cell cycle. Its potential as a therapeutic target is being explored due to its limited expression in normal tissues and overexpression in tumors, with inhibitors showing promise in preclinical studies by reducing cancer cell viability and enhancing sensitivity to chemotherapy.
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