Mouse Lymphocyte Antigen 75 (LY75) Protein

Product specifications

Proteins and Peptides

Lymphocyte Antigen 75 (LY75)

E. coli

Mouse

Unconjugated

Molecular Weight: Calculated MW: 35.9 kDa  Observed MW (SDS-PAGE): 36 kDa

Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Cys216-Pro503

Tag: N-terminal His tag

Recombinant

> 80%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized Reconstitute in ddH2O to a concentration of 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: 100 mM NaHCO<sub>3</sub>, 500 mM NaCl, pH 8.3, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.

Shipped within 5-7 working days.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

C-type lectin domain family 13 member B,CD205,LY-75,CLEC13B,DEC-205,GP200-MR6,Lymphocyte antigen 75

Protein LY75

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

LY75, also known as lymphocyte antigen 75, is a protein primarily involved in the immune system, specifically in antigen processing and presentation. LY75 is also referred to as DEC-205 (dendritic and epithelial cell 205) and is encoded by the LY75 gene in humans. LY75 belongs to the C-type lectin receptor family, which includes proteins involved in recognizing carbohydrate structures on pathogens, facilitating immune cell recognition, and initiating immune responses. It is a type I transmembrane protein highly expressed in dendritic cells (DCs), especially in lymphoid tissues, and also found on certain types of epithelial cells. Through its antigen-capturing ability, LY75 has a significant role in promoting immune tolerance and in the activation of T cells. LY75 functions as a receptor that binds to specific antigens, internalizes them, and processes them for presentation on major histocompatibility complex (MHC) molecules, primarily MHC class II. This makes it a critical component in activating adaptive immune responses, especially against infections, tumors, and other immune challenges. The ability of LY75 to capture and process antigens, combined with its expression pattern, positions it as an important target for immunotherapy, especially in contexts where modulation of the immune response, such as cancer immunotherapy and vaccine development, is desired.

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