Mouse Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) ELISA Kit
715€ (96 tests)
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935106861
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name
Mouse Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx154310
tested applications
ELISA
Description
Mouse Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse LDLRAP1 concentrations in tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1)
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.07 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates and other biological fluids. |
| Availability | Shipped within 5-7 working days. |
| Storage | Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | LDLRAP1, ARH, ARH1, ARH2, FHCB1, FHCB2, low density lipoprotein receptor adaptor protein 1, FHCL4 |
| Background | Elisa Kits for: LDLRAP1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Descripción
Low-Density Lipoprotein Receptor Adapter Protein 1 (LDLRAP1), also known as ARH (autosomal recessive hypercholesterolemia protein), is a crucial adaptor protein that plays a pivotal role in the trafficking and internalization of low-density lipoprotein (LDL) receptors. It is predominantly expressed in hepatocytes and other tissues involved in cholesterol homeostasis. LDLRAP1 functions by linking the cytoplasmic tail of LDL receptors to clathrin-coated pits, facilitating receptor-mediated endocytosis of LDL particles. Mutations in the LDLRAP1 gene are associated with autosomal recessive hypercholesterolemia (ARH), a rare genetic disorder characterized by elevated plasma LDL cholesterol levels due to impaired clearance of LDL from circulation. This protein's interaction with other cellular components, such as AP-2 and clathrin, highlights its essential role in lipid metabolism and receptor recycling. As a significant contributor to cholesterol regulation, LDLRAP1 has been a subject of intense research, particularly for developing therapeutic strategies targeting cholesterol-related disorders.
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