Mouse L-Lactate Dehydrogenase (LDHA) Protein
338€ (10 µg)
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935106861
info@markelab.com
name
Mouse L-Lactate Dehydrogenase (LDHA) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx690218
tested applications
SDS-PAGE
Description
Mouse L-Lactate Dehydrogenase Protein is a recombinant protein from Mouse produced in Human Cells. Recombinant Mouse L-lactate dehydrogenase is produced by our Mammalian expression system and the target gene encoding Met1-Phe332 is expressed with a 6His tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | L-Lactate Dehydrogenase |
| Host | Human |
| Origin | Mouse |
| Observed MW | Molecular Weight: 37.5 kDa Sequence Fragment: Met1-Phe332 Tag: C-terminal 6 His tag Validity: The validity for this protein is 6 months. |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Tested Applications | SDS-PAGE |
| Buffer | 20mM PB, 150mM NaCl, pH7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at < -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P06151 |
| Alias | LDHM, GSD11,PIG1,HEL-S-133P,lactate Dehydrogenase A,prolifeRation-inducing gene 19 |
| Background | Protein LDHA |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Lactate Dehydrogenase A (LDHA) is an enzyme that catalyzes the conversion of pyruvate to lactate in the final step of anaerobic glycolysis. LDHA plays a critical role in cellular energy metabolism, especially under hypoxic conditions, where it helps regenerate NAD+ for glycolysis. It is highly expressed in tissues with high glycolytic activity, such as skeletal muscle. In cancer, LDHA is upregulated as part of the Warburg effect, where tumor cells preferentially use glycolysis for energy production, even in the presence of oxygen. Elevated LDHA expression is associated with tumor growth, metastasis, and resistance to therapy, making it a target for anticancer therapies. Beyond cancer, LDHA is implicated in metabolic disorders and muscular diseases, highlighting its importance in both normal physiology and pathological conditions.
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