Mouse KISS1 Receptor (KISS1R) Protein
208€ (10 µg)
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935106861
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name
Mouse KISS1 Receptor (KISS1R) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx654122
tested applications
WB, SDS-PAGE
Description
Mouse Kisspeptin Receptor (KISS1R) Protein is a Recombinant Mouse protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Kisspeptin Receptor (KISS1R) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 11.0 kDa Observed MW: 14 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Arg331-Leu396 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | KISS1R,GPR54,Metastin receptor,hOT7T175,kiSS-1 receptor,kiSS-1R,KiSS1-derived peptide receptor |
| Background | Protein KISS1R |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
KISS1R, also known as GPR54, is a G protein-coupled receptor activated by kisspeptins, a family of peptide ligands derived from the KISS1 gene. KISS1R plays a crucial role in regulating the hypothalamic-pituitary-gonadal (HPG) axis, particularly in puberty onset and reproductive function. It is highly expressed in the hypothalamus, where kisspeptin signaling stimulates the secretion of gonadotropin-releasing hormone (GnRH), which in turn regulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release. This pathway is essential for normal sexual maturation, fertility, and reproductive hormone balance. Mutations in KISS1R are associated with hypogonadotropic hypogonadism, delayed puberty, and infertility. Beyond reproduction, KISS1R signaling is implicated in metastasis suppression, as kisspeptins inhibit cell migration and invasion in cancers such as melanoma and breast cancer. Dysregulation of KISS1R has also been linked to metabolic disorders and polycystic ovary syndrome (PCOS). Therapeutically, KISS1R agonists and antagonists are being explored for treating infertility, hormone-driven cancers, and reproductive disorders.
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