Mouse Kell Protein (KEL) Protein

221€ (10 µg)
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935106861
info@markelab.com
name
Mouse Kell Protein (KEL) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168736
tested applications
WB, SDS-PAGE
Description
Mouse KEL Protein is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Proteins and Peptides |
Immunogen Target | Kell Protein (KEL) |
Host | E. coli |
Origin | Mouse |
Conjugation | Unconjugated |
Observed MW | Molecular Weight: Calculated MW: 39.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ile49-Leu358 Tag: N-terminal His tag |
Expression | Recombinant |
Purity | > 97% |
Size 1 | 10 µg |
Size 2 | 50 µg |
Size 3 | 100 µg |
Size 4 | 200 µg |
Size 5 | 500 µg |
Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
Tested Applications | WB, SDS-PAGE |
Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
Availability | Shipped within 5-7 working days. |
Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | Q9EQF2 |
Alias | Kell blood group glycoprotein,ECE3,Kell,CD238, |
Background | Protein KEL |
Status | RUO |
Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Kell (KEL), also known as Kell metallo-endopeptidase, is a membrane-bound glycoprotein found primarily on the surface of red blood cells (RBCs). It is a key player in the Kell blood group system, which is one of the most important blood group systems for transfusion medicine. The Kell blood group system includes various antigens, with the K (K1) and k (K2) antigens being the most clinically significant. These antigens are carried by the Kell protein, and variations in the expression of these antigens are associated with immune reactions in transfusion therapy and hemolytic disease of the newborn (HDN). Kell is also a metalloendopeptidase, which means it has enzymatic activity and is capable of cleaving peptide bonds in substrates, a function typical of certain metalloproteins. The Kell protein is involved in regulating the function and integrity of red blood cells, and it also plays a role in the interaction of the RBC with the immune system. Despite its primary association with blood group antigens, Kell is part of a larger group of proteins with endopeptidase activity. The protein is encoded by the KEL gene, located on the X chromosome (Xp21.1). This gene is expressed at high levels in erythroid precursor cells and mature erythrocytes, with its most significant role being the expression of the Kell antigens.
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