Mouse Junctional Adhesion Molecule 3 (JAM3) Protein
1079€ (100 µg)
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935106861
info@markelab.com
name
Mouse Junctional Adhesion Molecule 3 (JAM3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx692077
tested applications
SDS-PAGE
Description
Mouse JAM3 Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the mouse JAM3 (NP_075766.1) extracellular domain (Met 1-Asn 241) was expressed, fused with a polyhistidine tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | JAM3 |
| Host | HEK293 cells |
| Origin | Mouse |
| Observed MW | Molecular Weight: 25 kDa Sequence Fragment: Met1-Asn241 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 94% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile 50mM Tris-Citrate, 300mM NaCl, pH 6.5. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_075766.1 |
| Alias | JAMC,JAM-2,JAM-3,JAM-C,Junctional adhesion molecule C |
| Background | Protein JAM3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
JAM3 is predominantly expressed in endothelial cells, platelets, and certain subsets of immune cells. Like JAM2, it features two extracellular Ig-like domains, a single transmembrane domain, and a cytoplasmic tail that interacts with scaffolding proteins to organize tight junctions. JAM3 plays a critical role in endothelial cell adhesion and platelet aggregation, as well as in the regulation of vascular permeability and angiogenesis. It interacts with other adhesion molecules, such as JAM2 and integrins, to mediate cell-cell interactions and leukocyte trafficking during immune responses. Additionally, JAM3 is essential for maintaining the integrity of the blood-brain barrier and regulating cell migration in response to injury or inflammation.
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