Mouse Interleukin 9 Receptor (IL9R) Protein
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Description
Interleukin 9 Receptor Protein is a recombinant Mouse protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Interleukin 9 Receptor (IL9R) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 28.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gly47-Gln257 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q01114 |
| Alias | CD129,IL-9R,IL-9 receptor |
| Background | Protein IL9R |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
The interleukin-9 receptor (IL9R) is a key component of the immune system, primarily involved in mediating the biological activities of interleukin-9 (IL-9), a cytokine secreted by T helper 2 (Th2) cells, mast cells, and a subset of T helper cells known as Th9 cells. IL-9 is known for its pleiotropic effects, influencing various cell types including mast cells, T cells, B cells, and epithelial cells. It is particularly important in immune responses, inflammatory processes, and allergic reactions. IL9R, through binding IL-9, initiates signaling cascades that play critical roles in the regulation of cell survival, proliferation, and differentiation in immune responses. The IL9R gene is located on the X chromosome (Xq28) in humans, which makes certain IL9R-related mutations have potential X-linked patterns of inheritance. Notably, IL9R signaling is involved in allergic diseases, asthma, and certain cancers. Additionally, IL-9 and IL9R have been implicated in autoimmune diseases and responses to infections, such as helminth infections. Due to its versatile role in immunity, IL9R is an area of interest for therapeutic strategies aiming to modulate immune responses, particularly in allergy and asthma, and cancer treatment.
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Interleukin 9 Receptor (IL9R) Antibody
The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene.
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