Mouse Interleukin-7 Receptor Subunit Alpha (IL7RA) Protein

Este producto es parte de IL7R - interleukin 7 receptor
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1079€ (100 µg)

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935106861
info@markelab.com
name
Mouse Interleukin-7 Receptor Subunit Alpha (IL7RA) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx691890
tested applications
SDS-PAGE

Description

Mouse IL7R alpha Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the mouse IL7Rα (NP_032398.3) extracellular domain (Met 1-Asp 239) was fused with a polyhistidine tag at the C-terminus.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
IL7R alpha
Host
HEK293 cells
Origin
Mouse
Observed MW
Molecular Weight: 26.5 kDa
Sequence Fragment: Met1-Asp239
Tag: C-terminal His tag
Validity: The validity for this protein is 12 months.
Expression
Recombinant
Purity
> 85% (SDS-PAGE)
Size 1
100 µg
Form
 
Tested Applications
SDS-PAGE
Buffer
Lyophilized from sterile PBS, pH 7.4.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P16872
NCBI Accession
NP_032398.3
Alias
Interleukin-7 receptor subunit alpha,ILRA,CD127,IL7RA,CDW127,IMD104,sIL-7R,lnc-IL7R,IL7Ralpha,IL-7Ralpha,IL-7R-alpha,IL-7 receptor subunit alpha; IL-7R subunit alpha,IL-7RA
Background
Protein IL7R
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

The interleukin-7 receptor (IL7R) is a critical component of immune system regulation, playing a major role in the development, survival, and homeostasis of T cells and, to a lesser extent, B cells. It is encoded by the IL7R gene and consists of two distinct subunits: IL-7Rα (CD127), which is unique to the IL-7 receptor, and γc (CD132), a common gamma chain shared with other cytokine receptors such as those for IL-2, IL-4, IL-9, IL-15, and IL-21. IL-7, the ligand for IL7R, is an essential cytokine that provides survival signals to developing lymphocytes and regulates their function, influencing T cell diversity, immune tolerance, and immune responsiveness. The IL7R signaling pathway has profound effects on immune system homeostasis, enabling it to counteract immune deficiencies, support immune recovery after depletion, and maintain immune memory. Dysregulation of IL7R, however, is implicated in a range of conditions, including severe combined immunodeficiency (SCID), autoimmune diseases, and certain cancers, especially T-cell acute lymphoblastic leukemia. The receptor’s pivotal role in lymphocyte biology makes it a significant target for immunological therapies and interventions.

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