Mouse Interleukin 5 Receptor alpha (IL5RA) Protein
234€ (10 µg)
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935106861
info@markelab.com
name
Mouse Interleukin 5 Receptor alpha (IL5RA) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168378
tested applications
WB, SDS-PAGE
Description
Interleukin 5 Receptor Alpha Protein is a recombinant Mouse protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Interleukin 5 Receptor alpha (IL5RA) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 22.4 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala41-Lys203 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P21183 |
| Alias | IL5R,CD125,CDw125,HSIL5R3,IL-5 receptor subunit alpha,IL-5R subunit alpha,IL-5R-alpha,IL-5RA |
| Background | Protein IL5RA |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Interleukin-5 receptor subunit alpha (IL5RA) is a protein critical for mediating immune responses involving eosinophils. Encoded by the IL5RA gene, this receptor forms a part of the IL-5 receptor complex, which is primarily responsible for binding interleukin-5 (IL-5), a cytokine crucial in regulating the growth, differentiation, and activation of eosinophils and basophils. Eosinophils, in particular, are involved in immune responses against parasitic infections and play a role in allergic inflammation and diseases such as asthma and eosinophilic esophagitis. IL-5, along with its receptor IL5RA, is also implicated in the development and maintenance of T-helper 2 (Th2)-mediated immune responses, which play a role in allergic diseases. By engaging IL5RA on eosinophils and other cells, IL-5 signaling promotes survival, activation, and accumulation of these cells at inflammatory sites. Due to its central role in driving eosinophil-mediated inflammation, IL5RA is a target for therapeutic interventions, especially in asthma, chronic rhinosinusitis with nasal polyps, and hypereosinophilic syndrome.
