Mouse Interleukin 5 Receptor alpha (IL5RA) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein IL5RA
proveedor
Abbexareference
abx168378Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Interleukin 5 Receptor Alpha Protein is a recombinant Mouse protein expressed in E. coli.
Background
Interleukin-5 receptor subunit alpha (IL5RA) is a protein critical for mediating immune responses involving eosinophils. Encoded by the IL5RA gene, this receptor forms a part of the IL-5 receptor complex, which is primarily responsible for binding interleukin-5 (IL-5), a cytokine crucial in regulating the growth, differentiation, and activation of eosinophils and basophils. Eosinophils, in particular, are involved in immune responses against parasitic infections and play a role in allergic inflammation and diseases such as asthma and eosinophilic esophagitis. IL-5, along with its receptor IL5RA, is also implicated in the development and maintenance of T-helper 2 (Th2)-mediated immune responses, which play a role in allergic diseases. By engaging IL5RA on eosinophils and other cells, IL-5 signaling promotes survival, activation, and accumulation of these cells at inflammatory sites. Due to its central role in driving eosinophil-mediated inflammation, IL5RA is a target for therapeutic interventions, especially in asthma, chronic rhinosinusitis with nasal polyps, and hypereosinophilic syndrome.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
Interleukin 5 Receptor alpha (IL5RA)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 22.4 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala41-Lys203 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
IL5RA
dry ice
No
availability
Shipped within 5-7 working days.
alias
IL5R,CD125,CDw125,HSIL5R3,IL-5 receptor subunit alpha,IL-5R subunit alpha,IL-5R-alpha,IL-5RA
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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