Mouse Interleukin-27 (IL27) Protein
338€ (10 µg)
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935106861
info@markelab.com
name
Mouse Interleukin-27 (IL27) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx690775
tested applications
SDS-PAGE
Description
Mouse Interleukin-27 Protein is a recombinant protein from Mouse produced in Human Cells. Recombinant Mouse Interleukin-27 subunit alpha and Interleukin-27 subunit beta is produced by our Mammalian expression system and the target gene encoding Tyr19-Pro228&Phe29-Ser234 is expressed with a 6His tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Interleukin-27 |
| Host | Human |
| Origin | Mouse |
| Observed MW | Molecular Weight: 49 kDa Sequence Fragment: Tyr19-Pro228 and Phe29-Ser234 Tag: C-terminal 6 His tag |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | PBS, 2mM EDTA, 5% Mannitol, pH7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store at < -20°C. |
| Dry Ice | No |
| UniProt ID | O35228, Q8K3I6 |
| Alias | p28,IL30,IL-27,IL27A,IL-27A,IL27p28,IL-27 subunit alpha,IL-27-A,Interleukin-30,p28 |
| Background | Protein IL27 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Interleukin 27 (IL27) is a heterodimeric cytokine that belongs to the IL-12 cytokine family and plays a pivotal role in regulating immune responses. IL-27 is produced primarily by antigen-presenting cells (APCs), such as dendritic cells, macrophages, and monocytes, following activation by various pathogen-associated signals. Its primary function is to modulate T cell responses, particularly by promoting the differentiation of T helper 1 (Th1) cells while simultaneously limiting excessive inflammatory responses through immune suppression. This dual role positions IL-27 as a key regulator of both pro-inflammatory and anti-inflammatory immune responses. IL-27 is composed of two distinct subunits: EBI3 (Epstein-Barr virus-induced gene 3) and p28, which together form the functional cytokine. IL-27 signals through a heterodimeric receptor composed of IL-27R (WSX-1) and gp130, activating a range of signaling pathways that control immune function, including the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway.
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