Mouse Interleukin 27A (IL27A) Protein
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935106861
info@markelab.com
Precio
247€ (10 µg)
Protein IL27
proveedor
Abbexareference
abx067515Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Mouse Interleukin-27 Subunit Alpha (IL27) is a recombinant Mouse protein from Mouseproduced in a Prokaryotic expression system (E. coli).
Background
Interleukin 27 (IL27) is a heterodimeric cytokine that belongs to the IL-12 cytokine family and plays a pivotal role in regulating immune responses. IL-27 is produced primarily by antigen-presenting cells (APCs), such as dendritic cells, macrophages, and monocytes, following activation by various pathogen-associated signals. Its primary function is to modulate T cell responses, particularly by promoting the differentiation of T helper 1 (Th1) cells while simultaneously limiting excessive inflammatory responses through immune suppression. This dual role positions IL-27 as a key regulator of both pro-inflammatory and anti-inflammatory immune responses. IL-27 is composed of two distinct subunits: EBI3 (Epstein-Barr virus-induced gene 3) and p28, which together form the functional cytokine. IL-27 signals through a heterodimeric receptor composed of IL-27R (WSX-1) and gp130, activating a range of signaling pathways that control immune function, including the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
Interleukin 27A (IL27A)
host
E. coli
conjugation
Unconjugated
form
Lyophilized Reconstitute in ddH2O to a concentration of 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 24.8 kDa Observed MW (SDS-PAGE): 18/24 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Phe29-Ser234 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: 100 mM NaHCO<sub>3</sub>, 500 mM NaCl, pH 8.3, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
IL27
dry ice
No
availability
Shipped within 5-7 working days.
alias
p28,IL30,IL-27,IL27A,IL-27A,IL27p28,IL-27 subunit alpha,IL-27-A,Interleukin-30,p28
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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