Mouse Interleukin 2 Receptor Alpha (IL2RA) Protein
1079€ (100 µg)
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935106861
info@markelab.com
name
Mouse Interleukin 2 Receptor Alpha (IL2RA) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx691889
tested applications
SDS-PAGE
Description
Mouse CD25 Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the mouse IL2RA (NP_032393.3) extracellular domain (Met 1-Lys 236) was expressed, with a C-terminal polyhistidine tag.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | CD25 |
| Host | HEK293 cells |
| Origin | Mouse |
| Observed MW | Molecular Weight: 26 kDa Sequence Fragment: Met1-Lys236 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 98% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_032393.3 |
| Alias | p55,CD25,IL2R,IMD41,TCGFR,IDDM10,Interleukin-2 receptor subunit alpha,IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA,TAC antigen |
| Background | Protein IL2RA |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Interleukin 2 receptor subunit alpha (IL2RA), also known as CD25, is a crucial component of the high-affinity interleukin-2 (IL-2) receptor complex, which is essential for regulating immune responses, particularly T-cell proliferation and survival. The IL-2 receptor plays a pivotal role in both adaptive immunity and immune tolerance, with IL2RA being one of the three subunits that form the IL-2 receptor complex. The IL-2 receptor system is critically involved in the regulation of T-cell homeostasis, immune activation, and the suppression of autoimmunity. IL2RA is primarily expressed on activated T cells, particularly regulatory T cells (Tregs), which are crucial for maintaining immune tolerance. It is also found on other immune cells, including activated B cells, dendritic cells, and natural killer (NK) cells under certain conditions. Importantly, IL2RA expression is tightly regulated, being upregulated upon T-cell activation and playing a central role in fine-tuning immune responses.
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