Mouse Interleukin-18 receptor accessory protein (IL18RAP) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
687.5€ (96 tests)
Elisa Kits IL18RAP
proveedor
Abbexareference
abx527804Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Interleukin-18 receptor accessory protein (IL18RAP) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Interleukin-18 receptor accessory protein concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
IL18RAP is an essential co-receptor that forms a heterodimeric complex with IL18R1 to enable IL-18-mediated immune signaling. It enhances the binding affinity of IL-18 to IL18R1, facilitating the recruitment of MyD88 and the activation of downstream signaling pathways, including NF-κB and MAPK, which drive the production of pro-inflammatory cytokines such as IFN-γ. IL18RAP is highly expressed on immune cells such as NK cells, macrophages, and Th1 T cells, where it regulates immune activation, cytokine release, and pathogen defense. It plays a pivotal role in promoting inflammation, antiviral immunity, and anti-tumor responses by enhancing IL-18 signaling efficiency. Dysregulation of IL18RAP is associated with inflammatory diseases, autoimmune disorders, and cancers, where aberrant IL-18 signaling exacerbates tissue damage and immune dysregulation. Functional studies show that loss of IL18RAP impairs IL-18 signaling, reduces cytokine production, and weakens immune responses, highlighting its critical role as a signaling cofactor in inflammation, immune defense, and disease progression.
Características del producto
category
ELISA Kits
immunogen target
Interleukin-18 receptor accessory protein (IL18RAP)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
alias
IL18RAP, ACPL, CD218b, CDw218b, IL-18R-beta, IL-18Rbeta, IL18RB, IL-1 R7,IL1R7
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
IL18RAP
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
Quizá le pueda interesar
Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
proveedor
Abbexareference
abx034109Tested Applications
ELISA, WB, IHC, FCMreactivity
Humanstatus
RUOclonality
PolyclonalIL18RAP is required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By similarity). Tog...
281.25€ (80 µl)
Ver másInterleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
proveedor
Abbexareference
abx037127Tested Applications
ELISA, WBreactivity
Humanstatus
RUOclonality
PolyclonalRabbit Polyclonal against the IL18RAP protein.
337.5€ (100 µg)
Ver másMouse Interleukin 18 Receptor Accessory Protein (IL18RAP) Protein
proveedor
Abbexareference
abx067490Tested Applications
WB, SDS-PAGEstatus
RUORecombinant Interleukin 18 Receptor Accessory Protein (IL18RAP) is a recombinant Mouse protein produced in E. coli using...
237.5€ (10 µg)
Ver más