Mouse Integrin Beta 4 (ITGb4) Protein

Este producto es parte de ITGB4 - integrin subunit beta 4
Product Graph
234€ (10 µg)

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935106861
info@markelab.com
name
Mouse Integrin Beta 4 (ITGb4) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167339
tested applications
WB, SDS-PAGE

Description

Integrin Beta 4 Protein is a recombinant Mouse protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Integrin Beta 4 (ITGb4)
Host
E. coli
Origin
Mouse
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 32.5 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Ser1098-Leu1356
Tag: N-terminal His tag
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
A2A863
Alias
Integrin beta-4,CD104,GP150,JEB5A,JEB5B
Background
Protein ITGB4
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Integrin subunit beta 4 (ITGB4) is a vital cell-adhesion molecule in the integrin family, specifically expressed in epithelial cells, where it plays a critical role in cell adhesion, signal transduction, and cellular responses to external stimuli. ITGB4 is notable for its involvement in forming hemidesmosomes, specialized structures that attach epithelial cells to the basement membrane, thereby contributing to tissue integrity, resilience, and structural stability. ITGB4 often pairs with the alpha 6 integrin subunit (forming the α6β4 integrin complex), allowing these integrins to specifically interact with laminins in the extracellular matrix. These interactions mediate a variety of essential biological processes, including cell adhesion, migration, differentiation, and survival. Due to its essential role in maintaining epithelial tissue structure and regulating cellular signaling, dysregulation or mutations in ITGB4 have been associated with a range of disorders, including epidermolysis bullosa and certain cancers.

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