Mouse Integrin Alpha 4 (ITGA4) Protein
208€ (10 µg)
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935106861
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name
Mouse Integrin Alpha 4 (ITGA4) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx653891
tested applications
WB, SDS-PAGE
Description
Mouse Integrin Alpha 4 (ITGa4) Protein is a Recombinant Mouse protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Integrin Alpha 4 (ITGA4) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 24.2 kDa Observed MW (SDS-PAGE): 24 kDa Concentration: Prior to lyophilization: 1000 µg/ml Sequence Fragment: Ala48-Phe233 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q00651 |
| Gene ID | 16401 |
| Alias | IA4,CD49D,Integrin alpha-4,CD49 antigen-like family member D,Integrin alpha-IV,VLA-4 subunit alpha |
| Background | Protein ITGA4 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Integrin subunit alpha 4 (ITGA4) is a critical member of the integrin family of cell surface receptors, which mediate cell-cell and cell-extracellular matrix (ECM) interactions. ITGA4 pairs with different beta subunits to form heterodimeric receptors that facilitate various biological processes, including immune cell migration, inflammation, tissue development, and cell adhesion. ITGA4 predominantly forms heterodimers with integrin beta 1 (ITGB1) to create the α4β1 integrin, also known as very late antigen-4 (VLA-4), and with integrin beta 7 (ITGB7) to form the α4β7 integrin. These integrins are particularly important in the immune system, where they mediate leukocyte adhesion and migration across blood vessels and into inflamed tissues.
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ITGA4, also named as CD49D, belongs to the integrin alpha chain family. ITGA4 is a receptor for fibronectin, VCAM1 and MADCAM1. ITGA4 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. It recognizes the sequence Q-I-D-S in VCAM1. I It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells ITGA4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
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