Mouse Inducible T-Cell Costimulator (ICOS) Protein
1079€ (100 µg)
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935106861
info@markelab.com
name
Mouse Inducible T-Cell Costimulator (ICOS) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx691314
tested applications
SDS-PAGE
Description
Mouse ICOS Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the mouse ICOS (Q9WVS0) extracellular domain (Met 1-Leu 142) was fused with the Fc region of human IgG1 at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | ICOS |
| Host | HEK293 cells |
| Origin | Mouse |
| Observed MW | Molecular Weight: 40.9 kDa Sequence Fragment: Met1-Leu142 Tag: C-terminal Fc tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 97% (SDS-PAGE) |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9WVS0 |
| Alias | Activation-inducible lymphocyte immunomediatory molecule,AILIM,CD278,CVID1 |
| Background | Protein ICOS |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Inducible T-cell costimulator (ICOS), a member of the CD28 family of costimulatory receptors, is expressed on activated T cells and plays a crucial role in modulating immune responses. ICOS, encoded by the ICOS gene, provides an essential costimulatory signal that promotes T cell activation, differentiation, and cytokine production. Upon activation by its ligand, ICOS ligand (ICOSLG or CD275), which is found on antigen-presenting cells (APCs) like B cells, dendritic cells, and macrophages, ICOS triggers intracellular signaling pathways that enhance T-cell effector functions. ICOS is crucial for both humoral and cell-mediated immunity. It enhances T-helper cell responses, particularly in the germinal centers of lymphoid tissues, where it influences B cell differentiation and supports antibody production. ICOS signaling also helps maintain the balance between effector and regulatory T cells, impacting inflammation control and immune tolerance. The ICOS/ICOSLG pathway is vital in the immune system's ability to fight infection and respond to vaccination, as well as in controlling immune tolerance to prevent autoimmune diseases.
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