Mouse Importin subunit alpha-4 (KPNA4) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Mouse Importin subunit alpha-4 (KPNA4) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx528293
tested applications
ELISA
Description
Mouse Importin subunit alpha-4 (KPNA4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Importin subunit alpha-4 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Importin subunit alpha-4 (KPNA4) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O35343 |
| Gene ID | 16649 |
| Alias | KPNA4,IPOA3, QIP1, SRP3, Importin subunit alpha-3 |
| Background | Elisa kits for KPNA4 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
KPNA4, also known as importin-α3, is a nuclear transport adaptor protein that recognizes classical nuclear localization signals (NLS) in cargo proteins and facilitates their nuclear import via the importin-β pathway. KPNA4 binds cargo proteins, such as transcription factors and kinases, forming a complex that translocates through the nuclear pore complex (NPC). It is widely expressed and plays critical roles in cell cycle regulation, transcriptional control, and stress responses. KPNA4 is implicated in viral replication by mediating the nuclear import of viral proteins in pathogens like HIV and influenza virus. Dysregulation of KPNA4 has been linked to cancers, where it enhances nuclear transport of oncogenic proteins and supports tumor progression. Knockdown studies show its role in maintaining proper cellular signaling, highlighting its importance in development, differentiation, and immune responses.
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The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.
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