Mouse Immunoglobulin iota chain (VPREB1) ELISA Kit

Product specifications

ELISA Kits

Immunoglobulin iota chain (VPREB1)

Mouse

Colorimetric

Quantitative

0.156 ng/ml - 10 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-15 working days. The validity for this kit is 6 months.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

P13372

22362

Immunoglobulin iota chain,IGI,IGVPB,VPREB,CD179a,CD179 antigen-like family member A,Protein VPreB1

Elisa kits for VPREB1

RUO

Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

VPREB1 (V-set pre-B cell surrogate light chain 1) is a gene encoding a protein that plays a crucial role in early B-cell development. During the development of B cells in the bone marrow, cells progress through several stages to create a functional B cell receptor (BCR), which is essential for the immune system to identify and respond to foreign antigens. VPREB1 encodes a component of the pre-B cell receptor (pre-BCR), a critical complex that allows for the transition of B cells from the pro-B cell to the pre-B cell stage. The pre-BCR includes the immunoglobulin heavy chain and two surrogate light chain components: the VpreB (encoded by VPREB1) and λ5 proteins. This pre-BCR complex is necessary to ensure only B cells with productive heavy chain gene rearrangements continue to develop, a process known as positive selection. Through interaction with the heavy chain, VPREB1 helps form a structurally similar but transient BCR to stimulate cell proliferation and survival at this early stage. This surrogate light chain helps enforce allelic exclusion, which ensures that each B cell produces a unique antibody specificity by allowing only one immunoglobulin heavy chain allele to be expressed. Thus, VPREB1 is vital for a highly selective B cell repertoire, preventing autoimmunity and contributing to immune diversity.

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