Mouse ICOS Ligand (ICOSLG) Protein (Active)
975€ (100 µg)
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Name
Mouse ICOS Ligand (ICOSLG) Protein (Active)
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx692017
Tested Applications
SDS-PAGE
Description
Mouse ICOS Ligand (ICOSLG) Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the mouse B7-H2 (NP_056605.1) extracellular domain (Met 1-Lys 279) was fused with a polyhistidine tag at the C-terminus.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | ICOS Ligand (ICOSLG) |
| Host | HEK293 cells |
| Assay Type | Activity: Active Sequence Fragment: Met1-Lys279 Tag: C-terminal His tag |
| Origin | Mouse |
| Observed MW | 27.8 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| NCBI Accession | NP_056605.1 |
| Alias | ICOS ligand, B7RP1,CD275,ICOSL,LICOS,B7RP-1,ICOS-L,IMD119,B7 homolog 2 |
| Background | Protein ICOSLG |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg of the protein as determined by the LAL method. |
Background
Inducible T-cell costimulator ligand (ICOSLG), also known as B7-H2 or CD275, is a critical immunoregulatory protein in the B7 family that provides costimulatory signals to T cells. ICOSLG serves as a ligand for ICOS (Inducible T-cell Costimulator), a receptor expressed on activated T cells. Through its interaction with ICOS, ICOSLG plays an essential role in modulating adaptive immune responses, particularly influencing T-cell differentiation, proliferation, and the formation of memory T cells. This interaction is crucial for both protective immunity and immune tolerance, enabling the immune system to respond robustly to pathogens while preventing autoimmunity. ICOSLG is primarily expressed on antigen-presenting cells (APCs), such as B cells, dendritic cells (DCs), macrophages, and certain epithelial cells in mucosal tissues. Its expression is inducible and can be upregulated during inflammation or immune activation by signals from pro-inflammatory cytokines like interferon-gamma (IFN-γ). The ICOS/ICOSLG axis is especially important for the regulation of germinal center formation in lymphoid tissues, where it facilitates B cell differentiation and antibody production. ICOSLG is also implicated in the maintenance of regulatory T cells (Tregs) and T-helper 17 (Th17) cells, thereby contributing to immune homeostasis and controlling inflammation.
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