Mouse Hydroxycarboxylic Acid Receptor 2 (HCAR2) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Mouse Hydroxycarboxylic Acid Receptor 2 (HCAR2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx526857
tested applications
ELISA
Description
Mouse Hydroxycarboxylic Acid Receptor 2 (HCAR2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Hydroxycarboxylic Acid Receptor 2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Hydroxycarboxylic Acid Receptor 2 (HCAR2) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.07 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9EP66 |
| Gene ID | 80885 |
| Alias | HCAR2,PUMAG,G-protein coupled receptor HM74A,Nicotinic acid receptor,Nic1,G protein-coupled receptor 109A,Niacr1,niacin receptor 1,HCA2,HM74a,HM74b,NIACR1,Puma-g,GPR109A |
| Background | Elisa kits for HCAR2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
HCAR2, also known as GPR109A, is a G protein-coupled receptor activated by nicotinic acid (niacin) and endogenous metabolites such as β-hydroxybutyrate (BHB). It is highly expressed in adipose tissue, immune cells, and the gut, where it plays a pivotal role in lipid metabolism, inflammation, and energy homeostasis. In adipocytes, HCAR2 activation inhibits cAMP production via Gi/o proteins, leading to the suppression of lipolysis and reduced free fatty acid release, which lowers circulating triglyceride levels. HCAR2 also mediates anti-inflammatory effects in immune cells, particularly in macrophages, by inhibiting pro-inflammatory cytokine production and promoting anti-inflammatory pathways, making it a key target in atherosclerosis and inflammatory diseases. HCAR2 is activated during fasting or ketogenic states through β-hydroxybutyrate, linking it to metabolic adaptations and energy conservation. Dysregulation of HCAR2 is implicated in metabolic disorders, cardiovascular disease, and neuroinflammation. Niacin-based therapies targeting HCAR2 are used to improve lipid profiles and manage dyslipidemia, highlighting its clinical relevance.
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