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Mouse Hyaluronidase PH-20 (SPAM1) ELISA Kit
proveedor
Abbexareference
abx390617Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Hyaluronidase PH-20 (SPAM1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse SPAM1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
Hyaluronidase PH-20 is an enzyme encoded by the SPAM1 gene in humans. It is a member of the hyaluronidase family , which have the capacity degrade hyaluronic acid—a major structural proteoglycan found in extracellular matrices and basement membranes. The human genome contains six genes related to hyaluronidases, with three of them (HYAL1, HYAL2, and HYAL3) clustered on chromosome 3, and the other three (HYAL4, SPAM1, and HYALP1) clustered on chromosome 7. The extensive homology between these six hyaluronidase genes suggests an ancient gene duplication event that occurred before the emergence of modern mammals. Hyaluronidase PH-20 plays a role in various physiological processes, including sperm function and fertilization, due to its ability to modify the extracellular matrix by degrading hyaluronic acid. Aliases: HYA1; HYAL PH-20; HYAL PH20; Hyal-PH20; HYAL1; HYAL3; HYAL5; HYALP_HUMAN; Hyaluronidase PH-20; Hyaluronoglucosaminidase PH-20; MGC26532; PH-20 Hyaluronidase; PH20; PH20 Hyaluronidase; SPAG15; SPAM-1; SPAM1; Sperm adhesion molecule 1; Sperm surface protein
Background
La hialuronidasa PH-20 es una enzima codificada por el gen SPAM1 en humanos. Es miembro de la familia de las hialuronidasas, que tienen la capacidad de degradar el ácido hialurónico, un proteoglicano estructural importante que se encuentra en las matrices extracelulares y las membranas basales. El genoma humano contiene seis genes relacionados con las hialuronidasas, tres de ellos (HYAL1, HYAL2 y HYAL3) agrupados en el cromosoma 3, y los otros tres (HYAL4, SPAM1 y HYALP1) agrupados en el cromosoma 7. La extensa homología entre estos seis genes de hialuronidasa sugieren un evento de duplicación de genes antiguo que ocurrió antes de la aparición de los mamíferos modernos. La hialuronidasa PH-20 desempeña un papel en diversos procesos fisiológicos, incluida la función de los espermatozoides y la fertilización, debido a su capacidad para modificar la matriz extracelular degradando el ácido hialurónico. Alias: HYA1; HIAL PH-20; HIAL PH20; hial-PH20; HIAL1; HIAL3; HIAL5; HYALP_HUMAN; Hialuronidasa PH-20; hialuronoglucosaminidasa PH-20; MGC26532; PH-20 Hialuronidasa; PH20; PH20 Hialuronidasa; SPAG15; SPAM-1; SPAM1; Molécula de adhesión de esperma 1; Proteína de la superficie del esperma
Características del producto
category
ELISA Kits
immunogen target
Hyaluronidase PH-20 (SPAM1)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.06 ng/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
SPAM1
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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