Mouse Heparin Cofactor II (SERPIND1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Heparin Cofactor II (HCII) concentrations in plasma. This assay has high sensitivity and excellent specificity for detection of Heparin Cofactor II (HCII)No significant cross-reactivity or interference between Heparin Cofactor II (HCII) and analogues was observed.
Inhibitory serpins have been shown to function in processes as diverse as DNA binding, chromatin condensation, immunoregulation ,apoptosis and haemostasis. Serpins are a broadly distributed protease inhibitors that use the conformational change as a mechanism of action. They are central in controlling many important proteolytic cascades. Phylogenetically Serpins superfamily organized in "Clades", named by letters. The following numbers shows the position in the glade. Serpin named as a SERPINXy, (where X is the clade and y is the number within that clade) many serpins also have alternative names from before this classification was proposed. Structuraly Serpinsare three β-sheets (A, B and C), 8-9 α-helices (termed hA-hI) and the reactive center known as reactive center loop (RCL). Heparin cofactor II (HCII), a protein encoded by the SERPIND1 gene, is a coagulation factor that inhibitsFactor IIa, and is a cofactor for heparin and dermatan sulfate. It is also related in many processes including inflammation, and cancer.
Se ha demostrado que las serpinas inhibidoras funcionan en procesos tan diversos como la unión al ADN, la condensación de cromatina, la inmunorregulación, la apoptosis y la hemostasia. Las serpinas son inhibidores de proteasas ampliamente distribuidos que utilizan el cambio conformacional como mecanismo de acción. Son fundamentales para controlar muchas cascadas proteolíticas importantes. Filogenéticamente superfamilia de Serpinas organizada en "Clados", nombradas por letras. Los siguientes números muestran la posición en el claro. Serpin nombrada como SERPINXy (donde X es el clado e y es el número dentro de ese clado). Muchas serpinas también tienen nombres alternativos antes de que se propusiera esta clasificación. Estructuralmente, las Serpins son tres láminas β (A, B y C), 8-9 hélices α (denominadas hA-hI) y el centro reactivo conocido como bucle del centro reactivo (RCL). El cofactor II de heparina (HCII), una proteína codificada por el gen SERPIND1, es un factor de coagulación que inhibe el factor IIa y es un cofactor de la heparina y el sulfato de dermatán. También está relacionado con muchos procesos, incluidos la inflamación y el cáncer.
ELISA Kits
Heparin Cofactor II (SERPIND1)
Mouse
0.156 ng/ml - 10 ng/ml
< 0.07 ng/ml
Sandwich
Quantitative
Colorimetric
Plasma
96 tests
5 × 96 tests
10 × 96 tests
HC2,LS2,HCF2,HCII,HLS2,THPH10,D22S673,Heparin cofactor 2,Heparin cofactor II,Protease inhibitor leuserpin-2,Serpin D1
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
SERPIND1
No
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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