Mouse GRB2 Related Adapter Protein 2 (GRAP2) ELISA Kit

Este producto es parte de GRAP - GRB2-related adapter protein
Mouse GRB2 Related Adapter Protein 2 (GRAP2) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for GRAP2

proveedor

Abbexa

reference

abx389462

Tested Applications

ELISA

reactivity

Mouse

status

RUO

clonality

Descripción

Mouse GRB2 Related Adapter Protein 2 (GRAP2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse GRAP2 concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

GRAP2, also known as GADS (GRB2-related adaptor downstream of SHC), is a hematopoietic-specific adaptor protein that serves as a key mediator in immune cell activation. It contains SH2 and SH3 domains, enabling interactions with critical proteins like LAT (linker for activation of T cells), SLP-76, and SOS to form multiprotein complexes (signalosomes). These complexes activate downstream signaling pathways, including NF-κB, MAPK/ERK, and actin cytoskeletal rearrangements required for immune synapse formation. GRAP2 is essential for T-cell receptor (TCR) and B-cell receptor (BCR) signaling, supporting processes like lymphocyte proliferation, antigen receptor-mediated activation, and cytokine production. GRAP2 is required for immune cell polarization, adhesion, and migration, ensuring effective adaptive immune responses. Dysregulation contributes to immune deficiencies, autoimmune diseases, and hematopoietic disorders, affecting lymphocyte development and function. Knockout studies reveal impaired T-cell development, antigen signaling defects, and reduced cytokine responses, highlighting its critical role in adaptive immunity and lymphocyte signaling.

Características del producto

category

ELISA Kits


immunogen target

GRB2 Related Adapter Protein 2 (GRAP2)


reactivity

Mouse


test range

78 pg/ml - 5000 pg/ml


sensitivity

< 46.9 pg/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

GRAP2, GADS, GRAP-2, GRB2L, GRBLG, GRID, GRPL, GrbX, Grf40, Mona, P38, GRB2-related adaptor protein 2, GRB2 related adaptor protein 2


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

GRAP2


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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