Mouse GRB2 Associated Binding Protein 2 (GAB2) Protein
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Description
GRB2 Associated Binding Protein 2 is a recombinant Mouse protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | GRB2 Associated Binding Protein 2 (GAB2) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 30.8 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gln357-Asp607 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | KIAA0571, Pp100,GRB2-Associated Binder |
| Background | Protein GAB2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
GAB2 is a key adaptor protein that links receptor tyrosine kinases and cytokine receptors to intracellular signaling cascades, including PI3K/Akt, MAPK, and STAT pathways. It is predominantly expressed in hematopoietic cells, where it regulates immune cell activation, differentiation, and cytokine signaling. GAB2 interacts with GRB2, SHP2, and PI3K to modulate immune responses, hematopoiesis, and mast cell degranulation. Dysregulation of GAB2 is associated with inflammatory diseases, autoimmunity, and cancer, particularly leukemia, breast cancer, and melanoma, where it enhances cell proliferation, survival, and migration. Knockout studies highlight defects in immune cell activation, mast cell responses, and hematopoietic development, demonstrating its importance in immune regulation.
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