Mouse Frizzled-5 (FZD5) Protein
1235€ (100 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Mouse Frizzled-5 (FZD5) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx691284
Tested Applications
SDS-PAGE
Description
Frizzled-5 (FZD5) protein is a recombinant Mouse protein expressed in CHO cells.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Frizzled-5 (FZD5) |
| Host | CHO cells |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Pro167 Tag: C-terminal Fc tag |
| Origin | Mouse |
| Observed MW | 42.9 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: Sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | Q9EQD0 |
| Alias | FZD5,HFZ5,C2orf31,frizzled family receptor 5,Fz5 |
| Background | Protein FZD5 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Background
FZD5 is a member of the Frizzled family of G protein-coupled receptors that primarily mediates canonical Wnt/β-catenin signaling and non-canonical Wnt pathways. It is widely expressed in tissues such as the gut, pancreas, brain, and placenta, playing critical roles in embryonic development, cell proliferation, and differentiation. FZD5 is essential for intestinal development and homeostasis, where it regulates Wnt-dependent stem cell maintenance and epithelial regeneration. In the central nervous system, FZD5 contributes to neural development and synaptic function. Its dysregulation is implicated in developmental disorders and diseases such as cancer. FZD5 overexpression in cancers like pancreatic and colorectal tumors enhances cell proliferation, survival, and resistance to therapies through Wnt/β-catenin activation. Additionally, FZD5 regulates angiogenesis by interacting with Wnt ligands, promoting vascular endothelial cell proliferation and survival. In placental biology, FZD5 is critical for trophoblast differentiation and vascular remodeling. Targeting FZD5 has emerged as a potential therapeutic strategy for cancer, inflammatory bowel disease, and other Wnt-driven pathologies due to its pivotal role in tissue homeostasis and disease progression.
Productos relacionados
Frizzled Homolog 5 (FZD5) Antibody
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling protei…
Ver producto
Frizzled Homolog 5 (FZD5) Antibody
Frizzled 5 Antibody is a Rabbit Polyclonal antibody against Human.…
Ver producto
Frizzled Homolog 5 (FZD5) Antibody
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling protei…
Ver producto