Mouse Frizzled Homolog 5 (FZD5) Protein
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Description
Mouse Frizzled-5 Protein is a recombinant protein from Mouse produced in CHO Stable Cells. A DNA sequence encoding the mouse FZD5 (Q9EQD0) (Met1-Pro167) was expressed with the Fc region of human IgG1 at the C-terminus.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Frizzled-5 |
| Host | CHO cells |
| Origin | Mouse |
| Observed MW | Molecular Weight: 42.9 kDa Sequence Fragment: Met1-Pro167 Tag: C-terminal Fc tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9EQD0 |
| Alias | FZD5,HFZ5,C2orf31,frizzled family receptor 5,Fz5 |
| Background | Protein FZD5 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
FZD5 is a member of the Frizzled family of G protein-coupled receptors that primarily mediates canonical Wnt/β-catenin signaling and non-canonical Wnt pathways. It is widely expressed in tissues such as the gut, pancreas, brain, and placenta, playing critical roles in embryonic development, cell proliferation, and differentiation. FZD5 is essential for intestinal development and homeostasis, where it regulates Wnt-dependent stem cell maintenance and epithelial regeneration. In the central nervous system, FZD5 contributes to neural development and synaptic function. Its dysregulation is implicated in developmental disorders and diseases such as cancer. FZD5 overexpression in cancers like pancreatic and colorectal tumors enhances cell proliferation, survival, and resistance to therapies through Wnt/β-catenin activation. Additionally, FZD5 regulates angiogenesis by interacting with Wnt ligands, promoting vascular endothelial cell proliferation and survival. In placental biology, FZD5 is critical for trophoblast differentiation and vascular remodeling. Targeting FZD5 has emerged as a potential therapeutic strategy for cancer, inflammatory bowel disease, and other Wnt-driven pathologies due to its pivotal role in tissue homeostasis and disease progression.
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